Suppressor of cytokine signaling-1 ameliorates dextran sulfate sodium-induced colitis in mice

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Suppressor of cytokine signaling-1 ameliorates dextran sulfate sodium-induced colitis in mice.

Inflammatory bowel disease (IBD) is a chronic disorder of the gastrointestinal tract. Although the etiology and pathogenesis of IBD remain unknown, pro-inflammatory cytokines including IFN-gamma play an important role in the development of IBD. Suppressor of cytokine signaling-1 (SOCS-1) is a crucial inhibitor of cytokine signaling, particularly of IFN-gamma. In this study, we investigated the ...

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ژورنال

عنوان ژورنال: International Immunology

سال: 2008

ISSN: 0953-8178,1460-2377

DOI: 10.1093/intimm/dxn033